Roger Narayan, Professor, UNC/NCSU Joint Department of Biomedical Engineering
Over the past decade, we have examined use of several additive manufacturing technologies such as digital micromirror device-based stereolithography, two photon polymerization, and piezoelectric inkjet printing to create small-scale hypodermic needle-shaped structures known as microneedles for transdermal drug delivery and transdermal sensing. For example, we have use additive manufacturing techniques to prepare arrays of hollow microneedles that may be used to transfer fluid to an electrochemical sensor from subsurface tissues. In several studies, we have integrated electrochemical sensors with arrays of hollow microneedles. Multiplexed microneedle sensors may potentially be used for simultaneous detection of several physiologically-relevant molecules. In addition, piezoelectric inkjet printing has been used to create microneedles for transdermal delivery of many types of drugs. In this talk, efforts to improve microneedle design and facilitate clinical translation will be considered.