As additively manufactured variants of permeant implants are becoming increasingly common place, advanced biomaterials that are capable of repairing and restoring native tissue morphology and function are beginning to emerge as the next step of medicine and patient care. To this end, the 3D-Painting biomaterial system was developed to permit the design of highly biofunctional, acellular biomaterials with tailored compositions and micro/nanostructures that can be rapidly 3D printed an extensive variety of formfactors. Through this combination of composition and microstructure, we are able to use the 3D printing process to create intentional microenvironments that are recognized and used by native cells and tissues — ultimately promoting natural tissue repair and regeneration. Beyond the extensive functionality of these engineered microenvironments, the 3D painting materials and 3D printing process permit an extensive variety of materials to be rapidly 3D printed at room temperature without any chemical or thermal modifications, resulting in end materials that are user-friendly and highly tissue regenerative. In this presentation, we will discuss how the Dimension Inx team has progressed the advanced 3D painting biomaterials technology platform from small-scale, laboratory and pre-clinical demonstrations, to quality-controlled, scaled additive production of bone reparative and regenerative products. This will primarily be demonstrated through updates on the technical, manufacturing and regulatory progress of the advanced hard tissue biomaterial, Hyperelastic Bone®. We will further highlight how these quality and manufacturing processes, adapted from existing processes, can be readily extended to other existing and yet-to-be-designed advanced tissue regenerative materials and off-the-shelf and patient-matched 3D printed products.
- Understand the general process by which new tissue regenerative materials can be designed and implemented in a 3D printing process.
- Understand the process by which new biomaterials and regenerative technologies can be taken through quality control and manufacturing processes necessary for product realization.
- Appreciate the importance of material microstructure with respect to tissue repair and regeneration.